Carbohydrate-modulated DNA photocleavage: Design, synthesis, and evaluation of novel glycosyl anthraquinones

Authors
Toshima, K Maeda, Y Ouchi, H Asai, A Matsumura, S
Citation
K. Toshima et al., Carbohydrate-modulated DNA photocleavage: Design, synthesis, and evaluation of novel glycosyl anthraquinones, BIOORG MED, 10(19), 2000, pp. 2163-2165
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
19
Year of publication
2000
Pages
2163 - 2165
Database
ISI
SICI code
0960-894X(20001002)10:19<2163:CDPDSA>2.0.ZU;2-7
Abstract
Novel and artificial anthraquinone-carbohydrate hybrids were designed and s ynthesized, and found to effectively cleave DNA under irradiation with a lo ng wavelength UV light and also exhibit cytotoxicity against HeLa S3 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.