Ld. Arnold et al., Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I, BIOORG MED, 10(19), 2000, pp. 2167-2170
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are
potent and selective inhibitors of lck in vitro; some compounds are selecti
ve for lck over src. Data are shown for two compounds demonstrating that th
ey are potent and selective inhibitors of IL2 production in cells. (C) 2000
Elsevier Science Ltd. All rights reserved.