Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of lck in vitro; some compounds are selecti ve for lck over src. Data are shown for two compounds demonstrating that th ey are potent and selective inhibitors of IL2 production in cells. (C) 2000 Elsevier Science Ltd. All rights reserved.