Af. Burchat et al., Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II, BIOORG MED, 10(19), 2000, pp. 2171-2174
Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are
novel, potent and selective inhibitors of lck in vitro. Exploration of C-6
position of the pyrrolo[2,3-d]pyrimidine and the terminal phenyl group stru
cture-activity relationship (SAR) is detailed. Compound 1 is orally active
in animal models. (C) 2000 Elsevier Science Ltd. All rights reserved.