The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors

Authors
Grant, EB Guiadeen, D Baum, EZ Foleno, BD Jin, HY Montenegro, DA Nelson, EA Bush, K Hlasta, DJ
Citation
Eb. Grant et al., The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors, BIOORG MED, 10(19), 2000, pp. 2179-2182
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
19
Year of publication
2000
Pages
2179 - 2182
Database
ISI
SICI code
0960-894X(20001002)10:19<2179:TSASOR>2.0.ZU;2-7
Abstract
beta-Lactam antibiotics such as the cephalosporins and penicillins have dim inished clinical effectiveness due to the hydrolytic activity of diverse be ta-lactamases, especially those in molecular classes A and C. A structure-a ctivity relationship (SAR) study of a high-throughput screening lead result ed in the discovery of a potent and selective non-beta-lactam inhibitor of class C beta-lactamases. (C) 2000 Elsevier Science Ltd. All rights reserved .