Enhanced Pneumocystis carinii activity of new primaquine analogues

Authors
Goodwin, TE Boylan, CJ Current, WL Byrd, JC Edwards, CB Fuller, DA Green, JL Larocca, CD Raney, KD Ross, AS Tucker, WA
Citation
Te. Goodwin et al., Enhanced Pneumocystis carinii activity of new primaquine analogues, BIOORG MED, 10(19), 2000, pp. 2205-2208
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
19
Year of publication
2000
Pages
2205 - 2208
Database
ISI
SICI code
0960-894X(20001002)10:19<2205:EPCAON>2.0.ZU;2-8
Abstract
New analogues of the venerable antimalarial drug primaquine have been synth esized and bioassayed in vivo against Pneumocystis carinii, a life-threaten ing infection common among immunosuppressed patients. Two of these new comp ounds are significantly more active than primaquine itself, and provide new information for future drug design and development in this area. (C) 2000 Elsevier Science Ltd. All rights reserved.