Biologically active oligodeoxyribonucleotides. Part 12: N-2-methylation of2 '-deoxyguanosines enhances stability of parallel G-quadruplex and anti-HIV-1 activity
M. Koizumi et al., Biologically active oligodeoxyribonucleotides. Part 12: N-2-methylation of2 '-deoxyguanosines enhances stability of parallel G-quadruplex and anti-HIV-1 activity, BIOORG MED, 10(19), 2000, pp. 2213-2216
2'-Deoxyguanosine residues of a 3',5'-end-modified hexadeoxyribonucleotide
(R-95288) with anti-HIV-1 activity were substituted with N-2-methyl-2'-deox
yguanosine (m(2)dG). These modified oligodeoxyribonucleotides (ODNs) showed
a 2-fold higher activity than R-95288. Also, the CD spectra of these ODNs
indicated that the m(2)dG modification stabilized the tertiary structure of
the G-quadruplex. (C) 2000 Elsevier Science Ltd. All rights reserved.