Juvenile myelomonocytic leukemia relapsing after allogeneic bone marrow transplantation successfully treated with interferon-alpha

We report a 5-year-old boy with juvenile myelomonocytic leukemia (JMML) whi ch relapsed after an allogeneic bone marrow transplant who was successfully treated with interferon-alpha (IFN-alpha). One year after starting the the rapy, he remains clinically well and in complete remission while continuing treatment with IFN-alpha and bestatin, Although the precise mechanism by w hich remission was induced is uncertain, a GVL effect combined with a direc t antileukemia effect of IFN-alpha may be responsible. Further assessment o f the role of IFN-alpha in relapsed JMML patients is warranted.