Medullary monoamine levels during experimental tooth movement

We investigated possible influence of nociception induced by experimental t ooth movement on the medullary monoaminergic inhibitory systems. Forty-eigh t hours after the start of the experimental tooth movement, significant inc reases in dorsal serotonin (5-HT), dopamine (DA), norepinephrine (NE), 5-hy droxyindoleacetic acid (5-HIAA), and dihydroxyphenylacetic acid (DOPAC) lev els were detected with ipsilateral dominance. These results suggest that th e nociception induced by experimental tooth movement might be under modulat ion of serotonergic, noradrenergic, and dopaminergic systems. (C) 2000 Else vier Science BN. All rights reserved.