Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

Authors
Silveira, DC Holmes, GL Schachter, SC Geula, C Schomer, DL
Citation
Dc. Silveira et al., Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats, BRAIN RES, 878(1-2), 2000, pp. 223-227
Citations number
31
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
878
Issue
1-2
Year of publication
2000
Pages
223 - 227
Database
ISI
SICI code
0006-8993(20000929)878:1-2<223:ISTGSA>2.0.ZU;2-Q
Abstract
We investigated whether basal forebrain cholinergic neurons influence the e xpression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesion ed rats had significantly shorter latencies to onset of generalized tonic-c lonic seizures than controls. Our findings suggest that basal forebrain cho linergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V. All rights reserved.