A novel intramolecular defluorinative cyclization approach to the synthesis of difluoromethylated quinazolic acid derivatives

Authors
Hao, J Ohkura, H Amii, H Uneyama, K
Citation
J. Hao et al., A novel intramolecular defluorinative cyclization approach to the synthesis of difluoromethylated quinazolic acid derivatives, CHEM COMMUN, (19), 2000, pp. 1883-1884
Citations number
24
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
19
Year of publication
2000
Pages
1883 - 1884
Database
ISI
SICI code
1359-7345(2000):19<1883:ANIDCA>2.0.ZU;2-U
Abstract
tert-Butyl 2-(difluoromethyl)-3-benzyl-6-methoxy-3,4-dihydro-4-quinazoline- 4-carboxylic ester (4) and its related 6-substituted esters, precursors of a new type of cyclic amino acid, were synthesized via intramolecular defluo rinative cyclization under basic conditions.