J. Hao et al., A novel intramolecular defluorinative cyclization approach to the synthesis of difluoromethylated quinazolic acid derivatives, CHEM COMMUN, (19), 2000, pp. 1883-1884
tert-Butyl 2-(difluoromethyl)-3-benzyl-6-methoxy-3,4-dihydro-4-quinazoline-
4-carboxylic ester (4) and its related 6-substituted esters, precursors of
a new type of cyclic amino acid, were synthesized via intramolecular defluo
rinative cyclization under basic conditions.