A one-step, enantioselective reduction of ethyl nicotinate to ethyl nipecotinate using a constrained, chiral, heterogeneous catalyst

Authors
Raynor, SA Thomas, JM Raja, R Johnson, BFG Bell, RG Mantle, MD
Citation
Sa. Raynor et al., A one-step, enantioselective reduction of ethyl nicotinate to ethyl nipecotinate using a constrained, chiral, heterogeneous catalyst, CHEM COMMUN, (19), 2000, pp. 1925-1926
Citations number
15
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
19
Year of publication
2000
Pages
1925 - 1926
Database
ISI
SICI code
1359-7345(2000):19<1925:AOEROE>2.0.ZU;2-H
Abstract
A chiral catalyst derived from 1,1'-bis(diphenylphosphino)ferrocene and anc hored within MCM-41 displays remarkable increases in both enantioselectivit y and activity, in the hydrogenation of ethyl nicotinate to ethyl nipecotin ate, when compared to an analogous homogeneous model compound.