Chemo- and regioselective crossed alkyne cyclotrimerisation of 1,6-diynes with terminal monoalkynes mediated by Grubbs' catalyst or Wilkinson's catalyst

Authors
Witulski, B Stengel, T Fernandez-Hernandez, JM
Citation
B. Witulski et al., Chemo- and regioselective crossed alkyne cyclotrimerisation of 1,6-diynes with terminal monoalkynes mediated by Grubbs' catalyst or Wilkinson's catalyst, CHEM COMMUN, (19), 2000, pp. 1965-1966
Citations number
28
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
19
Year of publication
2000
Pages
1965 - 1966
Database
ISI
SICI code
1359-7345(2000):19<1965:CARCAC>2.0.ZU;2-N
Abstract
A novel protocol for crossed alkyne cyclotrimerisations mediated by Grubbs' catalyst [RuCl2(=CHPh)(PCy3)(2)] allows the efficient synthesis of 4,6-sub stituted indolines with high regioselectivity, and it is complementary to a lkyne cyclotrimerisations mediated by Wilkinson's catalyst [RhCl(PPh3)(3)] allowing the regioselective synthesis of the corresponding 4,5-substituted isomers in many cases.