Synthesis and antimycobacterial, antifungal, and photosynthesis-inhibitingevaluation of some anilides of substituted pyrazine-2-carboxylic acids

Authors
Dolezal, M Vicik, R Miletin, M Kral'ova, K
Citation
M. Dolezal et al., Synthesis and antimycobacterial, antifungal, and photosynthesis-inhibitingevaluation of some anilides of substituted pyrazine-2-carboxylic acids, CHEM PAP-CH, 54(4), 2000, pp. 245-248
Citations number
18
Categorie Soggetti
Chemistry
Journal title
CHEMICAL PAPERS-CHEMICKE ZVESTI
ISSN journal
03666352 → ACNP
Volume
54
Issue
4
Year of publication
2000
Pages
245 - 248
Database
ISI
SICI code
0366-6352(2000)54:4<245:SAAAAP>2.0.ZU;2-Q
Abstract
Condensation of chlorides of substituted pyrazine-2-carboxylic acids with r ing-substituted anilines yielded a series of anilides of 6-chloropyrazine-2 -carboxylic, 5-(1,1-dimethylethyl) pyrazine-2-carboxylic or 6-chloro-5- (1, 1-dimethylethyl)pyrazine-2-carboxylic acids. Products were tested for their antimycobacterial. antifungal, and photosynthesis-inhibiting activity. Som e of them exhibited significative activity against Mycobacterium tuberculos is (inhibition > 50 % at MIC = 12.5 mu g cm(-3)). The most active compound (88 %) was 6-chloro-5-(1,1-dimethylethyl)pyrazine-2- carboxylic acid 3-fluo roanilide.