Ee. Jacobsen et al., Enantiopure derivatives of 1,2-alkanediols: Substrate requirements of lipase B from Candida antarctica, CHIRALITY, 12(9), 2000, pp. 654-659
Efficient methods for kinetic resolution of 1-phenoxy-2-butanol, 1-phenylme
thoxy-2-butanol, and 1-phenoxy-2-pentanol were developed using lipase B fro
m Candida antarctica as catalyst. Resolutions were performed in order to in
vestigate the substrate requirements needed to obtain a high E-value. The e
ffect of the substrate structure on E is different for transesterifications
in organic media as compared to hydrolysis. The influence of different acy
l donors on the E-value was also investigated. Chirality 12:654-659, 2000.
(C) 2000 Wiley-Liss, Inc.