Relationship between circadian blood pressure patterns and progression of early carotid atherosclerosis - A 3-year follow-up study

Background-Arterial hypertension is a major risk factor for cardiovascular damage. The results of several studies suggest that target organ damage is greater in hypertensive persons with high blood pressure variability. Methods and Results-During 3.3 years of follow-up, we studied the relations hip between circadian blood pressure changes and the progression of early c arotid atherosclerosis in 286 patients aged >55 years. Blood pressure patte rns were evaluated with a long-term blood pressure monitor, and the extent of atherosclerosis was measured as the intima-media wall thickness (IMT) of the common carotid artery. Patients were subdivided according to blood pre ssure variability. The progression of IMT was significantly greater in the patients with increased systolic blood pressure variability, (0.11 mm/y [95 % CI 0.09 to 0.14] versus 0.05 mm/y [0.03 to 0.08]: P<0.005) even after adj ustment for other risk factors. Multivariate regression analysis revealed t he daytime systolic blood pressure variability to be the best predictor for the progression of IMT. Raised daytime systolic brood pressure variability (>15 mm Hg) is associated with an increased relative risk of the developme nt of early atherosclerosis (3.9 [1.4 to 11.1]; P<0.01) and of cardiovascul ar events (1.87 [1.08 to 3.20]; P<0.01), Conclusions-The daytime systolic blood pressure variability is a strong pre dictor of early carotid atherosclerosis progression and is useful to define the risk-benefit ratio of therapeutic approaches.