A. Kamischke et al., Potential of norethisterone enanthate for male contraception: pharmacokinetics and suppression of pituitary and gonadal function, CLIN ENDOCR, 53(3), 2000, pp. 351-358
OBJECTIVE Gestagens are known to suppress gonadotrophins in women and are c
urrently also under investigation for the development of hormonal male cont
raceptives. The aim of the study was to assess the potential of norethister
one enanthate (NETE) for male contraception.
DESIGN AND MEASUREMENTS The suppressive effect of a single injection of 200
mg NETE on serum gonadotrophins, serum testosterone, lipids, spermatogenes
is, well-being and sexual function was evaluated in seven healthy men.
RESULTS In this single dose study treatment was well tolerated by ail volun
teers. NETE led to a rapid, profound and significant suppression of serum L
H (day 6 - day 10), FSH (day 2 - day 29), testosterone (day 1 - day 29 and
day 35) and SHBG (day 6 - day 35), At study end sperm counts were significa
ntly suppressed, Numbers of spontaneous erections (day 17, 23 and 26), numb
er of sexual fantasies (day 20 and 23) as well as libido (day 20 and 26) we
re significantly decreased compared to baseline. Ail other parameters inclu
ding lipids, augmented glucose, testicular volume and well-being showed no
significant alterations,
CONCLUSION Because of its strong, rapid and sustained suppression of serum
FSH and testosterone norethisterone enanthate offers great potential for ho
rmonal male contraception if combined with testosterone esters.