A study of hemorheological behaviour for patients with Alzheimer's diseaseat the early stages

To evaluate the change of hemorheological indexes for patients with Alzheim er's disease (AD) at the early stages and to discuss effects of these chang es on AD, high shear value of whole blood viscosity (eta(bh)), reduced high shear value of whole blood viscosity (r eta(bh)), low shear value of whole blood viscosity (eta(bl)), reduced low shear, value of whole blood viscosi ty (r eta(bl)), KT value of whole blood viscosity, hematocrit (HCT) and blo od plasma viscosity (eta(P)) were measured in 31 patients with probable AD at the early stages and 33 age-matched healthy subjects. There were signifi cant differences of all hemorheological indexes between AD group and contro l group except HCT. Step discriminant analysis revealed 81.25% of overall g roup-classified accuracy in a hemorheological discriminant function consist ing of eta(bl), r eta(bl), r eta(bh) and HCT. Significant difference of hem orheological indexes existed between AD and age-matched healthy control sub jects. The results showed that measurement of hemorheological indexes could be used as one of reference standards of diagnosis in AD.