The adverse effects of the supine position on lung function were first demo
nstrated in 1922. Demonstrations that moving patients with acute respirator
y distress syndrome from supine to prone could improve oxygenation date to
the mid-1970s. This article summarizes the current understanding of the mec
hanism by which the prone position has this effect and speculates on the ro
le that prone ventilation might have in limiting ventilator-induced lung in
jury.