Corpus callosum size in children with developmental language disorder

Using high-resolution in-vivo magnetic resonance morphometry of the midsagi ttal area of the corpus callosum (CC) and four callosal subareas in 21 chil dren with developmental language disorder (DLD) of the phonologic-syntactic type we found no significant anatomical differences in comparison to an ag e- and gender-matched normal control group. There was also no significant b etween-group difference when the similar to 7% smaller forebrain volume amo ng children with DLD was accounted for by relating CC measures to forebrain volume. Only a tendency towards a larger anterior and middle CC in relatio n to forebrain volume was found in DLD children. In our DLD children we fou nd the same relationship between CC midsagittal size and forebrain volume a s recently reported for normal adults, namely, that the CC area increases t o the two-third power of forebrain volume. (C) 2000 Elsevier Science B.V. A ll rights reserved.