ASSESSMENT OF HOMOCYSTEINE STATUS

Authors
REFSUM H FISKERSTRAND T GUTTORMSEN AB UELAND PM
Citation
H. Refsum et al., ASSESSMENT OF HOMOCYSTEINE STATUS, Journal of inherited metabolic disease, 20(2), 1997, pp. 286-294
Citations number
58
Categorie Soggetti
Endocrynology & Metabolism","Genetics & Heredity
Journal title
Journal of inherited metabolic disease → ACNP
ISSN journal
01418955
Volume
20
Issue
2
Year of publication
1997
Pages
286 - 294
Database
ISI
SICI code
0141-8955(1997)20:2<286:AOHS>2.0.ZU;2-H
Abstract
Plasma total homocysteine (tHcy) determination is used in the diagnosi s of homocystinuria, in cobalamin and folate deficiency and in cardiov ascular risk assessment. However, determination of tHcy includes many pitfalls which complicate the assessment of homocysteine status. In th e present article, we review basic knowledge for a rational use of pla sma tHcy in diagnostic as well as scientific work. The subjects dealt with are procedures for sample handling and processing, the principles of tHcy analyses, and genetic and acquired determinants of the plasma tHcy concentration.