Local drug delivery

Intensive research efforts are now focused on the development of new strate gies for more effective delivery of drugs to the central nervous system. Th ese strategies include chemical modification of drugs, disruption of the bl ood-brain barrier, and utilization of alternative routes for drug delivery. This paper focuses on local drug delivery for the treatment of brain tumor s, it reviews papers published in the past year on local chemotherapy and i mmunotherapy. Other aspects of local drug delivery are discussed, including convection-enhanced delivery and drug delivery via a controlled-release mi crochip. Curr Opin Oncol 2000, 12:187-193 (C) 2000 Lippincott Williams & Wi lkins, Inc.