MODIFICATION OF ORGAN PROTEIN-SYNTHESIS AFTER SURGICAL STRESS BY LOW-ENERGY DIETS WITH DIFFERENT LIPID GLUCOSE RATIOS/

The aim of this work was to study the effects df low energy parenteral diets with different lipid/glucose ratios on rat liver and jejunal mu cosa protein synthesis. The studied diets were: L0 (100 % glucose, con trol diet), L25 (25 % lipids: 75 % glucose), L50 (50 % lipids: 50 % gl ucose) and L75 (75 % lipids: 25 % glucose). All diets were isoenergeti c and isonitrogenated, with a standard amino acid content. The diets w ere assayed in 93 rats with open femoral fracture immobilized by Kirsc hner pin insertion. The diets were administered for 4 days. On the fif th day, liver and jejunal mucosa protein synthesis were determined. Hi ghest liver protein synthesis rates were obtained with the diet compos itions: lipid/carbohydrate ratio: 25 % lipids and 75 % carbohydrates ( expressed as energy ratio). A higher proportion of lipids significantl y decreases liver protein synthesis (p < 0.05). Jejunal mucosa protein synthesis followed the same pattern, with the same statistical differ ences.