Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant

Objective: To investigate the impact of maternal diet during breastfeeding on atopic sensitization of infants at risk. Design: Prospective cohort study. Setting: Turku University Central Hospital, Finland. Subjects and methods: Altogether 114 infants with a family history of atopi c disease were followed during their first year of life. The mothers comple ted a 4 day food record during breastfeeding just before the infants were 3 months old. Atopic sensitization of the infants was determined by a positi ve skin prick test result at 12 months. Results: Positive skin prick test reactivity to at least one antigen was de tected in 27/114 (24%) infants at 12 months. The energy intake of the mothe rs was low, mean 8.0 MJ/day (95% CI 7.7-8.3), and the proportion of energy derived from fat was high, mean 36.6 E% (95% CI 35.6-37.6). Atopic mothers had a higher intake of total fat and saturated fat and a lower intake of ca rbohydrate as a percentage of total energy intake than non-atopic mothers; P = 0.017, P = 0.050, P = 0.004 respectively. Maternal intake of saturated fat during breast-feeding was associated with atopic sensitization of the i nfant, OR = 1.16 (95% CI 1.001-1.36); P = 0.048 irrespective of the materna l atopic status. Conclusions: Our results show that an unbalanced maternal diet during breas tfeeding may be a risk factor underlying the later development of atopic se nsitization of the infant regardless of maternal atopic disease. The observ ation thus extends findings implying that early nutrition programmes the su bsequent health of the child to the risk of developing atopic disease.