Comparison of the effects of plant sterol eater and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet
Ma. Hallikainen et al., Comparison of the effects of plant sterol eater and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet, EUR J CL N, 54(9), 2000, pp. 715-725
Objective: To investigate cholesterol-lowering effects of stanol ester (STA
EST) and sterol ester (STEEST)enriched margarines as part of a low-fat diet
.
Design: According to a Latin square model randomized double-blind repeated
measures design with three test margarines and three periods.
Setting: Outpatient clinical trial with free-living subjects.
Subjects: Thirty-four hypercholesterolaemic subjects completed the study.
Interventions: Subjects consumed three rapeseed oil-based test margarines (
STAEST, STEEST and control (no added stanols or sterols)) as part of a low-
fat diet each for 4 weeks.
Results: Mean daily intake of total plant sterols plus stanols was 2.01-2.0
4g during the two test margarine periods. In reference to control, serum to
tal cholesterol was reduced by 9.2 and 7.3% with the STAEST and STEEST marg
arine, respectively (P < 0.001 for both). The respective reductions for low
-density lipoprotein (LDL) cholesterol were 12.7 and 10.4% (P < 0.001). The
cholesterol-lowering effects of the rest margarines did not differ signifi
cantly. The presence of apolipoprotein E4 allele had a significant effect o
n LDL cholesterol response during the STAEST margarine only. Serum sitoster
ol and campesterol increased by 0.83 and 2.77 mg/l with the STEEST (P < 0.0
01), respectively and decreased by 1.18 and 2.60 mg/l with the STAEST marga
rine (P < 0.001). Increases of serum sitostanol and campestanol were 0.11 a
nd 0.19 mg/l with the STAEST margarine (P < 0.001), repsectively. No signif
icant changes were found in serum fat-soluble vitamin and carotenoid concen
trations when related to serum total cholesterol.
Conclusions: STAEST and STEEST margarines reduced significantly and equally
serum total and LDL cholesterol concentrations as part of a low-fat diet.