Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine: potential antihypertensive agents - Part IX

The synthesis of oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihyd rothiopyrano[2,3-b]pyridine is described. These compounds exhibit a selecti ve beta-blocking activity, with a selectivity towards beta(2)-receptors. Gr oups in the N-1 position giving rise to a considerable steric hindrance led to a higher beta(2)-blocking selectivity, whereas groups creating a modera te hindrance caused a weak but significant decrease in beta(2)-antagonist p otency. Substitution of the N-1-R group with a sulfur atom led to compounds possessing beta(1)-, beta(2)- and beta(3)-blocking properties. Compounds 9 c(1) and 10a(1) showed a beta(3)-antagonist activity slightly lower than th at of propranolol. (C) Editions scientifiques et medicales Elsevier SAS.