New oxazole-based conformationally restricted peptidomimetics: Design and synthesis of pseudopeptides

Authors
Falorni, M Giacomelli, G Porcheddu, A Dettori, G
Citation
M. Falorni et al., New oxazole-based conformationally restricted peptidomimetics: Design and synthesis of pseudopeptides, EUR J ORG C, (18), 2000, pp. 3217-3222
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
18
Year of publication
2000
Pages
3217 - 3222
Database
ISI
SICI code
1434-193X(200009):18<3217:NOCRPD>2.0.ZU;2-O
Abstract
A general synthesis of a new class of optically active amino acids containi ng an oxazole moiety is described along with a strategy for their insertion into a peptidomimetic chain. A modified portion of endothelin-1 is prepare d as a potential receptor antagonist. The procedure presented is based on r eadily available materials and can be performed in multigram quantities.