Dual energy X-ray absorptiometry reference data for Greek population - Theimpact on diagnosis of using various normal ranges for comparison

Introduction: The interpretation of bone mineral density (BMD) measurements and the individual classification of a patient is based on a normal refere nce range. Unfortunately, not all the manufacturers include in their analys is-software reference values specific for each population. Methods and pati ents: In our study, using Lunar's DPX-L densitometer, we measured BMD of th e lumbar spine and the femur of 4400 healthy women aged (25-80) years and w e calculated the corresponding T- and Z-scores. Multiple regression analysi s was applied to examine the dependence of BMD on age and weight. Greek dat a was compared with American and Italian. Results: There was a statisticall y significant difference between Greek and American mean values of all age groups. The Italian normal range is closer to our data and can be reliably used at least as T-scores are concerned. Still, there is a small discrepanc y in Z-scores, which might influence patient management. Conclusion: We con clude that Greek reference range should be used for the assessment of osteo porosis of Greek population for better evaluation of bone status and approp riate treatment. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved .