Cleavage of yeast tRNA(Phe) with complementary oligonucleotide conjugated to a small ribonuclease mimic

Authors
Beloglazova, NG Sil'nikov, VN Zenkova, MA Vlassov, VV
Citation
Ng. Beloglazova et al., Cleavage of yeast tRNA(Phe) with complementary oligonucleotide conjugated to a small ribonuclease mimic, FEBS LETTER, 481(3), 2000, pp. 277-280
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
00145793 → ACNP
Volume
481
Issue
3
Year of publication
2000
Pages
277 - 280
Database
ISI
SICI code
0014-5793(20000922)481:3<277:COYTWC>2.0.ZU;2-S
Abstract
An oligonucleotide conjugate bearing a chemical construct mimicking the cat alytic center of ribonuclease A has been designed and studied. The conjugat e efficiently cleaves yeast tRNA(Phe) at a single site adjacent to the targ et complementary sequence. (C) 2000 Federation of European Biochemical Soci eties. Published by Elsevier Science B.V. All rights reserved.