Analysis of eight STR loci in two Hungarian populations

A collection of eight STR loci (D3S1358, FGA, D8S1179, D21S11, D18S51, D5S8 18, D13S317, D7S820) was used to generate allele frequency databases for tw o Hungarian population samples, Caucasians from the Budapest area and Roman ies from Baranya county. During the analysis two intermediate sized alleles and a sequence variant allele were observed at the D7S820 locus. All three types of allelic variants were found to have modification (deletion, inser tion, transversion) in the same block of a (T)(9) stretch located within th e 3' flanking region of each allele, which may indicate a possible higher m utation rate of this (T)(9) block. For the loci D3S1358 and D7S820 the Roma ny population database showed departures from Hardy-Weinberg equilibrium. T he forensic efficiency values for the Romany population were slightly diffe rent from those found in the Hungarian Caucasian population. Comparing the allele frequency values by G-statistic, calculating the F-st indices and wi th the pairwise comparisons of inter-population variance, the two Hungarian populations could be distinguished using data of the eight STR loci. (C) 2 000 Elsevier Science ireland Ltd. All rights reserved.