Phyto-Hypophyson (R) L for female infertility. Randomized, placebo-controlled, clinical double-blind study

Objective and Design: In a prospective, randomized, placebo-controlled, dou ble-blind study, the effects of Phyto Hypophyson L (Steierl-Pharma GmbH, He rrsching, Germany), an Agnus castus-containing homeopathic preparation, wer e investigated in 67 women with fertility disorders. Patients and Methods: 37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson L or placebo 3 times a day over 3 months or 3 cycles. Outcome Measure and Results: The outcome measure being spontaneous menstrua tion, improved concentration of progesterone in the luteal phase, shortenin g of the cycle, earlier ovulation, and pregnancy was achieved in 38 out of 67 women. It was achieved more often from women with oligomenorrhea in the Phyto Hypophyson L group compared to the placebo group (82 versus 45%, p = 0.021), However, there was no significant effect when viewing the whole gro up. The baby take-home rate during the therapy and 6 months after the end o f the therapy showed a ratio of 6:2 (18.7:6.4%), This result was not signif icant. Furthermore, in the oligomenorrhea verum group we observed a signifi cant increase of progesterone during the luteal phase compared to the oligo menorrhea placebo group. Only very few undesirable drug effects were observ ed. Conclusion: In women with sterility and oligomenorrhea, a treatment wit h Phyto Hypophyson L can be recommended over a period of 3-6 months.