Octreotide prevents postoperative adhesion formation by suppressing peritoneal myeloperoxidase activity

Background/Aims: Despite a great deal of effort to prevent the adhesion for mation, an ideal therapy or drug remains to be identified. The aim of this study was to investigate the effect of octreotide on adhesion prevention an d neutrophil infiltration. Methodology: Fourteen female Sprague-Dawley rats were subjected to a standa rd intraabdominal adhesion model operation. Octreotide group (n=7) rats wer e administered 20 mu g/kg octreotide intramuscular while control group (n=7 ) rats were given no treatment. On the 10th day the rats were decapitated a nd the degrees of adhesions were recorded and the plasma, peritoneal fluid, peritoneal tissue myeloperoxidase levels were determined. Results: Intraabdominal adhesions and peritoneal tissue myeloperoxidase lev els were significantly reduced in the octreotide group as compared to salin e treated adhesion group. Conclusions: We concluded that octreotide reduces the intraabdominal adhesi ons. This adhesion-preventive effect may be due to the inhibition of neutro phil infiltration.