Automatic registration of postmortem brain slices to MRI reference volume

A new strategy to register each slice of the postmortem brain to anatomical ly corresponding in-vivo MRI slices is presented. The approach relies on a recursive reslicing of the MRI volume using non-linear polynomial transform ations. Simulation studies to validate the approach and results using real data are presented. The results suggest the feasibility and practicability of second- and third-order polynomials to register postmortem images on a s lice-by-slice basis to corresponding MRI sections, Using this method, it is possible to investigate the pathology of a disease through routinely acqui red MRIs and postmortem brain images.