Evidence obtained from anecdotal reports, clinical observations, epidemiolo
gical research and prospective studies suggests that physical activity may
reduce an individual's risk for developing depression and may alleviate sym
ptoms in persons with mild to moderate depression. However; many studies ex
amining the antidepressant effects of exercise exhibit methodological limit
ations that prevent an adequate understanding of the relationship between p
hysical activity and depression. Additional research is needed to better de
termine the role of physical activity in the prevention and/or treatment of
depression so appropriate physical activity guidelines can be developed to
promote mental as well as physical health. Thus, the purpose of this paper
is to provide an overview of the research examining physical activity and
depression discuss potential mechanisms for an antidepressant effect of exe
rcise, identify limitations in prior research, provide suggestions for futu
re research, and offer recommendations for exercise prescription in depress
ed populations.