T. Onogi et al., Null mutation of the dam or seqA gene suppresses temperature-sensitive lethality but not hypersensitivity to novobiocin of muk null mutants, J BACT, 182(20), 2000, pp. 5898-5901
Escherichia coli mukF, mukE, and mukB null mutants have common phenotypes s
uch as temperature-dependent colony formation, anucleate cell production, c
hromosome cutting by septum closure, and abnormal localization of SeqA-DNA
clusters. We show here that the associated muk null mutations cause hyperse
nsitivity to novobiocin. Null mutation of either dam or seqA suppressed par
tially the temperature-sensitive lethality but failed to suppress the anucl
eate cell production and the hypersensitivity to novobiocin caused by muk n
ull mutations.