Fibrous tissue ingrowth and attachment to porous tantalum

This study determined the soft tissue attachment strength and extent of ing rowth to a porous tantalum biomaterial. Eight dorsal subcutaneous implants (in two dogs) were evaluated at 2, 8, and 16 weeks. Upon retrieval, all imp lants were surrounded completely by adherent soft tissue. Implants were har vested with a tissue flap on the cutaneous aspect and peel tested in a serv o-hydraulic tensile test machine at a rate of 5 mm/min. Following testing, implants were dehydrated ed in a solution of basic fuschin, defatted, embed ded in methylmethacrylate, and processed for thin-section histology. At 4, 8, and 16 weeks, the attachment strength to porous tant alum was 61, 71, an d 89 g/mm respectively. Histologic analysis showed complete tissue ingrowth throughout the porous tantalum implant. Blood vessels were visible at the interface of and within the porous tantalum material. Tissue maturity and v ascularity increased with time. The tissue attachment strength to porous ta ntalum was three- to six-fold greater than was reported in a similar study with porous beads. This study demonstrated that porous tantalum permits rap id ingrowth of vascularized soft tissue, and attains soft tissue attachment strengths greater than with porous beads. (C) 2000 John Wiley & Sons, Inc.