STUDY OF THE DELIVERY OF THE GD GENE OF PSEUDORABIES VIRUS TO ONE-DAY-OLD PIGLETS BY ADENOVIRUS OR PLASMID DNA AS WAYS TO BYPASS THE INHIBITION OF IMMUNE-RESPONSE BY COLOSTRAL ANTIBODIES

In the present study, it was shown that piglets with maternal antibodi es, which had been primed with a replication-defective adenovirus that expresses the pseudorabies virus (PRV) glycoprotein go and boosted wi th the Bartha vaccine strain at 10 weeks of age are equally protected clinically upon a challenge as piglets without maternal antibodies vac cinated with the same approach or with the Bartha vaccine strain alone . Priming with a plasmid that expresses go was less efficient. (C) 199 7 Elsevier Science B.V.