A clinical research practice can provide numerous benefits to a clinical ga
stroenterology practice. These benefits include new learning opportunities,
enhanced community image, increased referral base, and improved practice r
evenues for the practitioner, as well as new treatment opportunities for th
e patient. A deliberate, business-like approach with appropriate personnel
and space is necessary for a successful clinical research practice. All per
sonnel should have a thorough understanding of good clinical practices. Ave
nues for obtaining a research grant are available, even for novice investig
ators, if the site is patient and committed. The purpose of this review is
to explore the positive as well as the negative aspects of starting a clini
cal research practice, the requirements for getting the site started, findi
ng the first study grant, and tasks to be anticipated during the conduct of
a study.