Solitary fibrous tumors are immunophenotypically distinct from mesothelioma(s)

Citation
Mb. Morgan et Br. Smoller, Solitary fibrous tumors are immunophenotypically distinct from mesothelioma(s), J CUT PATH, 27(9), 2000, pp. 451-454
Citations number
24
Categorie Soggetti
Dermatology
Journal title
JOURNAL OF CUTANEOUS PATHOLOGY
ISSN journal
03036987 → ACNP
Volume
27
Issue
9
Year of publication
2000
Pages
451 - 454
Database
ISI
SICI code
0303-6987(200010)27:9<451:SFTAID>2.0.ZU;2-E
Abstract
Introduction: Solitary fibrous tumor is a soft tissue tissue tumor of unkno wn histogenesis. Based upon histologic similarities and CD-34 expression, i t has been suggested that these neoplasms bear some relationship to mesothe lioma, and may represent its extra-pleural equivalent. Methods: In order to further investigate this possible relationship, we exa mined a series of five dermal and five extra-cutaneous solitary fibrous tum ors with antibodies directed against the mesothelial markers calretinin and HBME-1. Results: AU the lesions failed to stain with the antibodies tested. This su ggests that despite some similar histologic and immunophenotypic features, these lesions are not immunophenotypically identical. Mesotheliomas are CD- 34-(+), calretinin(+), HBME-1(+), while solitary fibrous tumors are CD-34(), calretinin(-), HBME-1(-). Conclusions: The histogenesis of solitary fibrous tumor remains elusive. It is unlikely that tumor location or tumor de-differentiation accounts for t he dichotomous staining properties, as these neoplasms show a similarly ben ign histologic appearance regardless of location.