Synthesis and structural study of novel 1,4,5,6,7,8-hexahydroquinolines

Authors
Suarez, M Verdecia, Y Ochoa, E Martin, N Martinez, R Quinteiro, M Seoane, C Soto, JL Novoa, H Blaton, N Peeters, OM De Ranter, C
Citation
M. Suarez et al., Synthesis and structural study of novel 1,4,5,6,7,8-hexahydroquinolines, J HETERO CH, 37(4), 2000, pp. 735-742
Citations number
42
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
37
Issue
4
Year of publication
2000
Pages
735 - 742
Database
ISI
SICI code
0022-152X(200007/08)37:4<735:SASSON>2.0.ZU;2-9
Abstract
A new series of 1,4,5,6,7,8-hexahydroquinolines (9a-j) has been synthesized and their structural features studied by X-ray analysis and theoretical ca lculations at semiempirical and ab initio levels. A good correlation is fou nd between the most stable conformation predicted for compounds 9 and that obtained by experimental X-ray diffraction for 9h. The obtained geometrical features for 9 are similar to those found for other related active calcium modulators.