Synthesis of N-methyl-4-pyridyl-1,2,3,4-tetrahydroisoquinolines via a Pictet-Spengler cyclisation

Authors
Prat, L Bureau, R Daveu, C Levacher, V Dupas, G Queguiner, G Bourguignon, J
Citation
L. Prat et al., Synthesis of N-methyl-4-pyridyl-1,2,3,4-tetrahydroisoquinolines via a Pictet-Spengler cyclisation, J HETERO CH, 37(4), 2000, pp. 767-771
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
37
Issue
4
Year of publication
2000
Pages
767 - 771
Database
ISI
SICI code
0022-152X(200007/08)37:4<767:SONVAP>2.0.ZU;2-Y
Abstract
The synthesis of N-methyl-4-pyridyl-1,2,3,4-tetrahydroisoquinolines (6a,b,c ) was achieved via a Pictet-Spangler cyclization of an activated amino grou p derivatized in a carbamate form. The obtained compounds have been designe d as potential serotonin analogs.