Inhibition of T-lymphocyte proliferation by cucurbitacins from Picrorhiza scrophulariaeflora

Authors
Smit, HF van den Berg, AJJ Kroes, BH Beukelman, CJ van Ufford, HCQ van Dijk, H Labadie, RP
Citation
Hf. Smit et al., Inhibition of T-lymphocyte proliferation by cucurbitacins from Picrorhiza scrophulariaeflora, J NAT PROD, 63(9), 2000, pp. 1300-1302
Citations number
24
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
9
Year of publication
2000
Pages
1300 - 1302
Database
ISI
SICI code
0163-3864(200009)63:9<1300:IOTPBC>2.0.ZU;2-P
Abstract
Two cucurbitacin aglycons were isolated from the dried rhizomes of Picrorhi za scrophulariaeflora and Were identified as 25-acetoxy-2,3,16,20-tetrahydr oxy-9-methyl-19-norlanosta-5,23-dien-22-one (picracin, 1) and 2,3,16,20,25- pentahydroxy-9-methyl-19-norlanosta-5,23-dien-22-one (deacetylpicracin, 2). Both compounds inhibit mitogen-induced T-lymphocyte proliferation at an IC 50 value of 1 mu M.