8-O-methylsclerotiorinamine, antagonist of the Grb2-SH2 domain, isolated from Penicillium multicolor

Authors
Nam, JY Kim, HK Kwon, JY Han, MY Son, KH Lee, UC Choi, JD Kwon, BM
Citation
Jy. Nam et al., 8-O-methylsclerotiorinamine, antagonist of the Grb2-SH2 domain, isolated from Penicillium multicolor, J NAT PROD, 63(9), 2000, pp. 1303-1305
Citations number
11
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
9
Year of publication
2000
Pages
1303 - 1305
Database
ISI
SICI code
0163-3864(200009)63:9<1303:8AOTGD>2.0.ZU;2-M
Abstract
A new secondary metabolite, 8-O-methylsclerotiorinamine (1), was isolated f rom a strain of Penicillium multicolor, and its structure was established u sing NMR spectroscopy and chemical evidence. The metabolite inhibited signi ficantly the binding between the Grb2-SH2 domain and the phosphopeptide der ived from the Shc protein and also blocked the protein-protein interactions of Grb2-Shc in cell-based experiments, with IC50 values of 5.3 and 50 mu M , respectively.