Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum

Authors
Weiss, CR Moideen, SVK Croft, SL Houghton, PJ
Citation
Cr. Weiss et al., Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum, J NAT PROD, 63(9), 2000, pp. 1306-1309
Citations number
26
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
9
Year of publication
2000
Pages
1306 - 1309
Database
ISI
SICI code
0163-3864(200009)63:9<1306:AOEAIN>2.0.ZU;2-A
Abstract
Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro a gainst chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falcipa rum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[ 2,3-b]furan-4,9-dione possessed good activity against both strains [IC50 va lues 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.