Jy. Jiang et al., Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases, J NEUROSURG, 93(4), 2000, pp. 546-549
Object. The goal of this study was to investigate the protective effects of
long-term (3-14 days) mild hypothermia therapy (33-35 degrees C) on outcom
e in 87 patients with severe traumatic brain injury (TBI) (Glasgow Coma Sca
le score less than or equal to 8).
Methods. In 43 patients assigned to a mild hypothermia group, body temperat
ures were cooled to 33 to 35 degrees C a mean of 15 hours after injury and
kept at 33 to 35 degrees C for 3 to 14 days. Rewarming commenced when the i
ndividual patient's intracranial pressure (ICP) returned to the normal leve
l. Body temperatures in 44 patients assigned to a normothermia group were m
aintained at 37 to 38 degrees C. Each patient's outcome was evaluated 1 yea
r later by using the Glasgow Outcome Scale. One year after TBI, the mortali
ty rate was 25.58% (11 of 43 patients) and the rate of favorable outcome (g
ood recovery or moderate disability) was 46.51% (20 of 43 patients) in the
mild hypothermia group. In the normothermia group, the mortality rate was 4
5.45% (20 of 44 patients) and the rate of favorable outcome was 27.27% (12
of 44 patients) (p < 0.05). Induced mild hypothermia also markedly reduced
ICP (p < 0.01) and inhibited hyperglycemia (p < 0.05). The rates of complic
ation were not significantly different between the two groups.
Conclusions. The data produced by this study demonstrate that long-term mil
d hypothermia therapy significantly improves outcomes in patients with seve
re TBI.