Neuroblastomatous recurrence of ganglioglioma - Case report

This case is believed to be the first reported recurrent intracranial gangl ioglioma with purely neuroblastomatous malignant transformation. A complete macroscopic resection of a right frontal lobe tumor in an 18-year-old woma n revealed differentiated ganglioglioma. Seven years later a large, well-de marcated recurrent tumor was again macroscopically totally resected in the same patient. Histological analysis showed malignant transformation in only the neuronal component of the original tumor. A review of the literature o n recurrent gangliogliomas and their malignant transformation is included.