Dibutyltin perfluoroalkanecarboxylates: synthesis, NMR characterization and in vitro antitumour activity

Authors
Kemmer, M Dalil, H Biesemans, M Martins, JC Mahieu, B Horn, E de Vos, D Tiekink, ERT Willem, R Gielen, M
Citation
M. Kemmer et al., Dibutyltin perfluoroalkanecarboxylates: synthesis, NMR characterization and in vitro antitumour activity, J ORGMET CH, 608(1-2), 2000, pp. 63-70
Citations number
37
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANOMETALLIC CHEMISTRY
ISSN journal
0022328X → ACNP
Volume
608
Issue
1-2
Year of publication
2000
Pages
63 - 70
Database
ISI
SICI code
0022-328X(20000825)608:1-2<63:DPSNCA>2.0.ZU;2-E
Abstract
Three dibutyltin perfluoroalkanecarboxylates have been synthesized, charact erized by H-1-, C-13-, F-19- and Sn-117-NMR, Mossbauer, IR and mass spectro scopy. The structure of tetra-n-butylbis(trifluoroacetato)distannoxane has been elucidated by X-ray crystallography. The in vitro antitumour activity of the three compounds against seven human tumour cell lines was found to b e as high as or even higher than that for reference compounds used clinical ly. (C) 2000 Published by Elsevier Science S.A.