A multi-element ICP-MS survey method as an alternative to the heavy metalslimit test for pharmaceutical materials

Authors
Wang, TB Wu, J Hartman, R Jia, XJ Egan, RS
Citation
Tb. Wang et al., A multi-element ICP-MS survey method as an alternative to the heavy metalslimit test for pharmaceutical materials, J PHARM B, 23(5), 2000, pp. 867-890
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
23
Issue
5
Year of publication
2000
Pages
867 - 890
Database
ISI
SICI code
0731-7085(200010)23:5<867:AMISMA>2.0.ZU;2-4
Abstract
A multi-element inductively coupled plasma-mass spectrometry (ICP-MS) surve y method has been demonstrated as an alternative to the antiquated 'heavy m etals limit test' prescribed by United States Pharmacopoeia (USP), European Pharmacopoeia (EP), and British Pharmacopoeia (BP), for drug substances, i ntermediates, and raw materials. The survey method is simple, fast, sensiti ve, semi-quantitative to quantitative, and includes all the elements which can be analyzed by atomic spectroscopy. (C) 2000 Elsevier Science B.V. All rights reserved.