Evaluation of alkali metal binding selectivities of caged aza-crown ether ligands by microelectrospray ionization/quadrupole ion trap mass spectrometry
Sm. Blair et al., Evaluation of alkali metal binding selectivities of caged aza-crown ether ligands by microelectrospray ionization/quadrupole ion trap mass spectrometry, J AM SOC M, 11(10), 2000, pp. 884-891
Citations number
32
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Microelectrospray ionization mass spectrometry (MESI-MS) is used to evaluat
e alkali metal binding selectivities of a variety of macrocyclic compounds.
Well-studied crown ethers are used to validate the MESI-MS method. A quant
itative correlation between MESI mass spectral ion intensities and solution
equilibrium distributions of complexes is obtained for the mixtures contai
ning a single host and different alkali metal guest ions. The MESI-MS metho
d is successfully applied for the determination of the alkali metal binding
selectivities of a series of cage-functionalized aza-crown ethers and rele
vant model compounds in methanol and chloroform solutions. The binding sele
ctivities parallel previous results obtained using conventional spectrophot
ometric extraction methods. Structural differences in the host compounds, s
uch as the presence of a cage functionality, binding cavity size, and overa
ll flexibility, cause significant changes in the binding selectivities. (J
Am Soc Mass Spectrom 2000, 11, 884-891) (C) 2000 American Society for Mass
Spectrometry.