Photosensitivity associated with treatment with triflusal

Background Triflusal is a fluorinated aspirin derivative with antiplatelet properties, which is used in Spain for the management and prevention of thr omboembolic disease. Case report A 91-year-old female developed a systemic photosensitivity reac tion 15 days after beginning triflusal preventive treatment (300 mg/12 h) f or prior transient ischaemic attack. Photobiological study showed an abnorm al response to light in areas exposed to ultraviolet B and A radiation, wit h a photopatch test positive to both triflusal and its main metabolite. The se observations suggested a causal relation between triflusal and the clini cal findings, as described in previous reports. Conclusions The few cases reported to date and the clinicopathological feat ures of this case suggested an immunological response as the most likely ca use of the reaction.