Crosslinking of the corneal collagen by UV-radiation with Riboflavin for the mode of treatment melting ulcera of the cornea, first results of four patients

Background: Corneal melting is a serious condition and in many cases maybe managed only by surgery. UV-radiation with Riboflavin is a new method that may stop the melting process of the cornea. Patients and method: Four patients suffering from melting ulcera of the cor nea of various origin underwent a single UV-radiation. Two ultraviolet diod es were used emitting light with an wavelength of 370 nm with an energy of 2,5 mW/cm(2). The radiation time was 30 minutes. Before he radiation was pe r-formed 2-3 drops of 0,11% Riboflavinsolution were applied to the cornea. The treatment area was 6-7 mm in diameter, Results: After the treatment in three of the four patients the melting proc ess of the cornea stopped. At least temporarily, a surgical procedure could be delayed. Conclusion: Because of the absence of any side-effects in serious cases the method is recommended prior to surgery.